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In a study published in the journal Toxicology, researchers examined the effects of exposing human colon cancer cell line (HTC116) titanium dioxide food additives in vitro. “In the absence of cytotoxicity, E171 was accumulated in the cells after 24 hours of exposure, increasing granularity and reactive oxygen species, inducing alterations in the molecular pattern of nucleic acids and lipids, and causing nuclei enlargement, DNA damage and tubulin depolymerization,” the scientists wrote. Researchers removed the additive from the culture, then examined the results 48 hours later. They found, “The removal of E171 was unable to revert the alterations found after 24 h of exposure in colon cells. In conclusion, exposure to E171 causes alterations that cannot be reverted after 48 h if E171 is removed from colon cells.”

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  • In conclusion, hypromellose (HPMC) is an essential component in the pharmaceutical industry, offering versatility and functionality in various drug formulations. Its precise usage, based on the percentage present, plays a pivotal role in determining the effectiveness and performance of the final product. As research continues to explore new applications and modifications of HPMC, its significance in the pharmaceutical sector is likely to grow even further.
  • Hydroxyethyl cellulose (HEC) is a versatile and widely used polymer derived from cellulose, a natural polymer found in plant cell walls. It is an essential ingredient in various industries due to its unique properties, including thickening, suspending, and stabilizing capabilities. As a result, the global hydroxyethyl cellulose manufacturers play a crucial role in meeting the demands of these sectors.
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  • WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Due to its tailored structure, HPMC finds applications in diverse fields. In the pharmaceutical industry, it is used as a binder, disintegrant, and viscosity enhancer in tablet formulations. In construction, it serves as a thickener, water retention agent, and additive for mortar and plaster. Additionally, it is employed in the paint and coatings sector to improve flow and leveling properties.
  • HEC is derived from cellulose, a natural polymer found in plants, and is produced by reacting cellulose with ethylene oxide to introduce hydroxyethyl groups onto the cellulose backbone. This modification increases the polymer's solubility in water and makes it suitable for various applications.
  • In the food industry, HPMC serves as a thickener, emulsifier, texturizer, and stabilizer. It helps improve the texture and mouthfeel of ice cream, sauces, and dressings. Moreover, HPMC's film-forming characteristics are utilized in confectionery products, where it helps create a smooth, non-sticky surface on breath mints and other candies. The use of HPMC also extends shelf life by preventing dehydration and maintaining product integrity.
  • The Importance of HPMC Viscosity Grades in Pharmaceutical Formulations
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  • In the food industry, HPMC is used as a thickening and stabilizing agent in a variety of products, including sauces, soups, and desserts. Its ability to improve texture, prevent crystallization, and enhance mouthfeel has made it a popular ingredient in processed foods.